A controlled clinical study of chlorpromazine and reserpine in chronic schizophrenia.

Since their recent introduction into clinical practice, chlorpromazine and reserpine have been widely used in the treatment of the schizophrenias. Studies of schizophrenic patients treated with chlorpromazine have been published by Vaughan, Leiberman, and Cook (1955), Kinross-Wright (1955), Goldman (1955), Charatan (1954), Labhardt (1954) and Anton-Stephens (1954); treatment with reserpine has been reported by Foote (1955), Kline (1954), Hollister, Krieger, Kringel, and Roberts (1955), Kline and Stanley (1955), Tasher and Chermak (1955), Campden-Main and Wegielski (1955), Noce, Williams, and Rapaport (1955), Barsa and Kline (1955), and Glynn (1955). The claims made by these workers for the two drugs are not dissimilar, but only the study of Kinross-Wright attempts to compare their efficacy. It seemed desirable, therefore, to try and assess the relative merits of the drugs as accurately as possible.